Seeking recommendation for maker of highly customized license plate frame

I'm probably not going to be much help, but perhaps you could get someone to do the artwork on adhesive vinyl and wrap a plain frame with it. I like your idea, but that's the only thought I have in how to implement it.
 
I would suggest looking through etsy.com for somebody who does either painting or applique. I have had custom work done through etsy with excellent results, and this kind of thing is really what it's best for.
 
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