Chicago to Gatlinburg Ride -- advice/suggestions requested

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As it stands now, we'd leave Chicago on a Saturday morning and arrive in Gatlinburg toward the end of the day Sunday....300-350 each day...probably a combo of interstate and state highways with some back roads tossed in once we get to southern OH and into KY. We would head back from Gatlinburg probably Friday stopping someplace along the way and returning home on Saturday or Sunday. While in Gatlingburg, our day trips probably would not exceed 200 miles round trip.